Masyn Winn belted two homers and Miles Mikolas allowed just three hits over 5 1/3 innings to lead the St. Louis Cardinals to a 6-0 win over the host Cincinnati Reds in the opener of a day-night doubleheader on Wednesday.

Mikolas (1-2) struck out four and walked none before being relieved with one out in the sixth. Kyle Leahy pitched out of a second-and-third jam in the sixth and followed with a scoreless seventh.

With two outs in the ninth, Victor Scott II belted a three-run homer before Lars Nootbaar and Winn hit back-to-back blasts off Alexis Diaz in a five-run inning as the Cardinals won for just the third time in 15 road games.

The game was a makeup from Tuesday night’s rainout in Cincinnati.

Elly De La Cruz extended his hitting streak to 13 and on-base streak to 18 with a first-inning single to center for the Reds, who had their five-game win streak snapped. Gavin Lux walked but went hitless in three official at-bats to end his hitting streak at 12.

With one out in the first, Winn drove a first-pitch sinker from Reds starter Brady Singer 400 feet off the facade of the upper deck in left for a 1-0 lead. Singer (4-1) suffered his first loss in a Cincinnati uniform, allowing just one run on two hits over six innings, walking three and striking out four.

The game was a stark contrast from Singer’s first three starts when he received 30 runs of support and went 3-0.

Cincinnati’s Tyler Callihan was recalled from Triple-A Louisville and made his major league debut in left field, going 0-for-2 before coming out for a pinch hitter in the eighth. Callihan took the roster spot of Jeimer Candelario, who was placed on the 10-day injured list before the game with a lumbar spine strain.

Home plate umpire Bruce Dreckman ejected St. Louis manager Oliver Marmol in the top of the eighth after Marmol argued a strike call from the dugout.