Louisville’s Isaac Brown was helped away from the Virginia Tech sideline with 5:40 left in the game.
Brown was grabbing at the back of his right leg after a 10-yard carry that was negated by a holding penalty.
Brown has 130 yards on 16 carries with a 52-yard TD run. He leads the nation with an 8.7 rushing average.
Brown has not missed a game this season, but he has been limited by injuries in three games. He has five 100-yard games this season; the Cardinals are 5-0 in those games.
On October 25, he rushed for a season-high 205 yards against Boston College.
